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HelpTest Code QMPSS Monoclonal Protein Study, Quantitative, Serum
Ordering Guidance
Additional Testing Requirements
Quantitation of monoclonal protein alone is not considered an adequate screen for monoclonal gammopathies. When screening a patient or establishing a first-time diagnosis for a monoclonal gammopathy, order FLCS / Immunoglobulin Free Light Chains, Serum in addition to this test.
Specimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 2 mL Serum total; 2 separate plastic vials, each containing 1 mL serum
Collection Instructions: Centrifuge and aliquot serum into 2 plastic vials, each containing 1 mL
Useful For
Aiding in the diagnosis and monitoring of monoclonal gammopathies, when used in conjunction with free light chain studies
This test alone is not considered an adequate screen for monoclonal gammopathies.
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| QMPTS | Quantitative M-protein Isotype, S | No | Yes |
| IGA | Immunoglobulin A (IgA), S | Yes, (Order IMMG or IGA) | Yes |
| IGM | Immunoglobulin M (IgM), S | Yes, (Order IMMG or IGM) | Yes |
| IGG | Immunoglobulin G (IgG), S | Yes, (Order IMMG or IGG) | Yes |
| TMAB1 | Therapeutic Antibody Administered? | No | Yes |
Reflex Tests
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| IFXED | Immunofixation Delta and Epsilon, S | Yes | No |
| IGD | Immunoglobulin D (IgD), S | Yes | No |
| IGE | Immunoglobulin E (IgE), S | Yes | No |
Method Name
QMPTS: Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS)
IGG, IGA, IGM: Nephelometry
TMAB1: Patient Information
Reporting Name
Quantitative M-protein Study, SSpecimen Type
SerumSpecimen Minimum Volume
Serum: 2 Plastic vials, each containing 0.75 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Refrigerated (preferred) | 28 days |
| Frozen | 28 days | |
| Ambient | 7 days |
Reject Due To
| Gross hemolysis | OK |
| Gross lipemia | Reject |
| Gross icterus | OK |
Day(s) Performed
Monday through Friday
Report Available
2 to 4 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
0077U
82784 x 3
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| QMPSS | Quantitative M-protein Study, S | 104266-2 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| TMAB1 | Therapeutic Antibody Administered? | 98855-0 |
| IGA | Immunoglobulin A (IgA), S | 2458-8 |
| IGG | Immunoglobulin G (IgG), S | 2465-3 |
| IGM | Immunoglobulin M (IgM), S | 2472-9 |
| 620875 | M-protein GK | 74862-4 |
| 620876 | M-protein GL | 74863-2 |
| 620877 | M-protein AK | 74864-0 |
| 620878 | M-protein AL | 74865-7 |
| 620879 | M-protein MK | 74866-5 |
| 620880 | M-protein ML | 74867-3 |
| 620881 | Glycosylation | 104267-0 |
| 620874 | Flag, M-protein Isotype | 94400-9 |
| 621012 | QMPTS Interpretation | 69048-7 |
Special Instructions
Forms
If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:
-Hematopathology/Cytogenetics Test Request (T726)
-Renal Diagnostics Test Request (T830)
-General Request (T239)