Ordering Guidance

This test does not apply to any fluorescence in situ hybridization (FISH) assays. If specimen is to be held for FISH testing, order HOLDF / Hematologic Disorders, Fluorescence In Situ Hybridization (FISH) Hold, Varies.

For plasma cell proliferative disorders such as multiple myeloma, fluorescence in situ hybridization (FISH) studies will detect chromosome anomalies with prognostic significance much more often than conventional chromosome studies. The recommended test in this situation is PCPDS / Plasma Cell Proliferative Disorder, High-Risk with Reflex Probes, Diagnostic FISH Evaluation, Bone Marrow. Due to limited clinical utility, chromosome analysis is not recommended for plasma cell neoplasms.(1)

Shipping Instructions

Advise Express Mail or equivalent if not sent via courier service.

Necessary Information

Provide a reason for testing and bone marrow pathology report (if available) with each specimen. The laboratory will not reject testing if this information is not provided, but appropriate testing and interpretation may be compromised or delayed.

Specimen Required

Submit only 1 of the following specimens:

Preferred:

Specimen Type: Bone marrow

Container/Tube:

Preferred: Yellow top (ACD)

Acceptable: Green top (sodium heparin), lavender top (EDTA)

Specimen Volume: 1 to 2 mL

Collection Instructions: Invert several times to mix bone marrow.

Acceptable:

Specimen Type: Blood

Container/Tube:

Preferred: Yellow top (ACD)

Acceptable: Green top (sodium heparin), lavender top (EDTA)

Specimen Volume: 6 mL

Collection Instructions: Invert several times to mix blood.